Supporting Psychosis Innovation

Learn about Best Practices and Evidence-Based Treatments for Psychosis

SPIRIT faculty were part of an expert panel convened in 2018 by the American Psychiatric Association Integrated Care Workgroup and charged with addressing the role of psychiatry in improving the physical health of persons with serious mental illness. The group reviewed the peer-reviewed and gray literature and developed a set of recommendations to key stakeholders, including clinicians, health care organizations, researchers, and policy makers. Their findings were published in the Journal Psychiatric Services.

SPIRIT faculty contributed to the most recent systematic review of pharmacologic and psychosocial interventions for adults with schizophrenia spectrum disorders. The results, which were published by the Agency for Healthcare research and Quality, can be accessed here:

Findings from this systematic review were used to inform updates to the American Psychiatric Association’s most recent revisions to the national Practice Guidelines for the Treatment of Patients with Schizophrenia (3rd Edition).”

About Psychosis

What is Psychosis?

Psychosis is a temporary state in which the individual’s experience of the world is markedly different from others in their culture or subculture. Psychosis pertains to a set of experiences or symptoms. Contrary to popular belief, psychosis and psychotic-like experiences are common, modifiable, understandable, and treatable.

Psychosis can look different for each person, but is often characterized by one or more of the following experiences: unusual thinking that is particularly resistant to contradictory evidence and out-of-sync with prevailing beliefs held by others in one’s culture or subculture (e.g., beliefs that the TV or radio contain personal references), perceptual disturbances (e.g., hearing voices or seeing things that others are not able to perceive), and unusual or disorganized behavior (e.g., behavior that is odd for a given setting or circumstance, such as wearing heavy winter gear in the summer). Collectively, these symptoms are known as the “positive psychotic symptoms” because they represent experiences that are in addition to someone’s typical, or baseline, experience of the world.

Psychosis may also be characterized by negative symptoms, which are so-termed because they represent the absence of typical experiences. This includes increased isolation from others, a lack of motivation, difficulty expressing or identifying emotions, decrease in the range of emotions felt or the intensity of those emotions, and reduced speech.

Psychosis may also be accompanied by cognitive symptoms, which can include memory deficits, difficulties planning, difficulty organizing one’s thoughts, impulsivity, and challenges with concentration and attention. Many people may also experience mood symptoms, such as increased sadness, irritability or increased agitation, thoughts of suicide, loss of interest, or physical symptoms (e.g., loss of appetite, fatigue).

Psychosis is not an “all-or-nothing” phenomenon; rather, psychosis, like other experiences or symptoms, exists on a continuum. This means that individuals may experience a spectrum of psychotic symptoms, ranging from less severe to more severe, and less frequent to more frequent. We are each susceptible to psychosis, and we can each take steps to prevent and treat psychosis.

Psychosis is treatable, and treatment works.

Find Out More…

The following list of websites will link you to credible sources of information about psychosis. There is a lot of misinformation on the web about psychosis and schizophrenia spectrum disorders, but these websites have been vetted to ensure that you have access to accurate and reliable information, based on the current state of the field.


National Institute of Mental Health (NIMH)

Connect with other families navigating life with psychosis:

Connect with others who experience psychosis

University of Washington’s Central Assessment of Psychosis Service (CAPS)

The SPIRIT Lab at University of Washington aims to enhance support to the New Journeys teams in shortening the duration of untreated psychosis, ascertain the estimated point prevalence of psychosis risk states in regions of our state, enhance diagnostic accuracy for young people presenting challenging diagnostic pictures to our New Journeys teams, and identify individualized treatment needs based on a thorough clinical assessment.

The Central Assessment of Psychosis Service (CAPS) will extend specialized expertise in screening and assessment of psychosis and psychosis-risk states by offering remote-delivered psychological testing (tele-evaluation) and professional consultation (teleconsultation) to help accurately identify youth and young adults earlier in the course of a psychotic illness.

Click here to learn more about CAPS.

Early Psychosis Care across the Pacific Northwest

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